Stručni rad
https://doi.org/https://doi.org/10.48188/hczz.6.1.8
OXIDATIVE STRESS, ANTIOXIDANT DEFENSE AND PHYSICAL ACTIVITY: BALANCE BETWEEN DAMAGE AND ADAPTATION INAGING PROCESS
Manuela Kušec
orcid.org/0009-0003-8210-5550
; Veleučilište Ivanić-Grad
*
Iva Vajda
orcid.org/0009-0008-8306-5585
; Ministarstvo poljoprivrede, šumarstva i ribarstva
Goran Bobić
; Sveučilište u Zagrebu Kineziološki fakultet
* Dopisni autor.
Sažetak
The aging process is characterised by a gradual decline in the functional capacities of the organism, which is largely a con-sequence of oxidative stress - an imbalance between the production of reactive oxygen species and the efficiency of antioxidant defence. Although reactive oxygen species can damage biomolecules, in moderate amounts they act as important signalling factors that promote adaptive mechanisms and enhance cellular resistance. Physical activity represents one of the key modulators of oxida-tive status because it induces a temporary increase in reactive oxygen species, thereby activating a hormetic response - an increase in the activity of antioxidant enzymes, mitochondrial biogenesis, and improvement of redox homeostasis. Regular moderate-inten-sity physical activity at approximately 50-70% of maximal oxygen uptake or 60-75% of maximum heart rate contributes to reducing chronic oxidative stress, slowing biological aging, and helping maintain functional independence. In contrast, high-intensity or frequent training loads without adequate recovery may lead to the accumulation of oxidative stress and adverse effects on the body. Understanding the relationship between oxidative damage and adaptation enables the development of personalised strategies to prevent degenerative diseases and promote healthy aging.
Ključne riječi
OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; EXERCISE; ANTIOXIDANTS; AGING; HORMETIC EFFECT
Hrčak ID:
349469
URI
Datum izdavanja:
12.7.2026.
Posjeta: 0 *