ADMET and DMPK, Vol. 14 , 2026.
Izvorni znanstveni članak
https://doi.org/https://doi.org/10.5599/admet.3487
Bimetallic metal organic framework modified screen printed electrode for simultaneous voltammetric determination of calcium folinate and methotrexate
Ameer Mahmood Shaker
; Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq
Batool Nassir Hamran
; Department of Basic Sciences, College of Dentistry, University of Kerbala, 56001, Karbala, Iraq
Ala’a R. Shaker
; Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq
Hussein Ali Bahrani
; College of Nursing, University of Al-Ameed, Department of Chemistry, Collage of Education for pure science, University of Kerbala, Iraq
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* Dopisni autor.
Sažetak
Background and purpose: Calcium folinate (CFT) is a medication used as an antidote to methotrexate (MTT) and as a vitamin against anaemia. MTT is used to treat a variety of carcinomas, including acute lymphoblastic leukaemia, head and neck cancer, gastric cancer, breast cancer and choriocarcinoma. Experimental approach: A nanocomposite made of Fe and Mg linked to a 1,4-benzene dicarboxylate ligand metal organic framework (FeMg-BDC MOF) was created for this investigation. Using field emission scanning electron microscopy, the morphology and structure of the Mg-BDC MOF were examined. Next, a screen-printed electrode modified with a synthetic nanocomposite (FeMg-BDC MOF/SPE) was used as the working electrode for voltammetric detection of CFT. Key results: The FeMg-BDC MOF/SPE demonstrated high electrocatalytic activity for CFT oxidation as compared to unmodified SPE. The limit of detection is 0.04 μM, and under ideal conditions, the oxidation peak currents of CFT show a linear relationship with its concentration in the range of 0.1 to 390.0 μM. Additionally, when MTT was present, the FeMg-BDC MOF/SPE demonstrated good activity toward CFT determination. The oxidation peak potentials' separation (255 mV) shows that differential pulse voltammetry may be used to detect these two medications simultaneously. Conclusion: the devised sensor's applicability was confirmed with outstanding results using CFT and MTT assays in pharmaceutical specimens and urine samples.
Ključne riječi
Cancer disease; chemotherapy drugs; electrochemical sensor
Hrčak ID:
350226
URI
Datum izdavanja:
8.8.2026.
Posjeta: 0 *