Izvorni znanstveni članak

https://doi.org/https://doi.org/10.5599/admet.3433

Electrochemical detection of illicit sibutramine adulteration in herbal weight-loss products using an AgNPs-ErGO modified electrode

Nguyen Dang Thuy Anh ; University of Medicine and Pharmacy, Hue University, Vietnam
Vo Thi Cam Le ; University of Medicine and Pharmacy, Hue University, Vietnam
Huynh Van Chung ; Buon Ma Thuot Medical University, Vietnam
Ngo Thi Thanh Xuan ; Drug, cosmetic and food quality control center of Hue city, Vietnam
Hoang Thi Minh Nguyet ; Hue Central Hospital, Vietnam
Pham Thi Thanh Ha ; Hanoi University of Pharmacy, Vietnam
Ha Thuy Trang ; University of Education, Hue University, Vietnam
Le Hoang Hao ; University of Medicine and Pharmacy, Hue University, Vietnam
Dao Thi Cam Minh ; University of Medicine and Pharmacy, Hue University, Vietnam *
Nguyen Hai Phong ; University of Science, Hue University, Vietnam *
Dinh Quang Khieu ; University of Science, Hue University, Vietnam *

* Dopisni autor.

Sažetak

Background and purpose: Sibutramine is a synthetic anti-obesity drug that has been banned or restricted in many countries due to serious cardiovascular risks. However, its illegal adulteration in herbal weight-loss products remains a public health concern. This study aimed to develop a simple, sensitive, and reliable electrochemical method for the determination of sibutramine in herbal weight-loss products using a silver-nanoparticle-electrochemically reduced graphene oxide modified glassy carbon electrode. Experimental approach: Graphene oxide, electrochemically reduced graphene oxide, silver nanoparticles and AgNPs-ErGO nanocomposite were synthesized and characterized using X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy combined with energy dispersive X-ray spectroscopy, Raman spectroscopy and high-resolution transmission electron microscopy. The AgNPs-ErGO-modified glassy carbon electrode was fabricated and used for sibutramine detection by linear sweep voltammetry. Experimental parameters affecting the analytical signal were optimized. The method was validated according to AOAC guidelines and compared with an HPLC-DAD reference method. Key results: The AgNPs-ErGO/GCE exhibited improved electrochemical response toward sibutramine compared with bare and other modified electrodes. The developed method showed good selectivity, linearity, precision, accuracy, and sensitivity for sibutramine determination. Application to commercial herbal weight-loss samples demonstrated the suitability of the proposed method for real sample analysis, with results comparable to those obtained by HPLC-DAD. Conclusion: The AgNPs-ErGO/ /GCE-based electrochemical method provides a rapid, cost-effective, and reliable approach for detecting sibutramine adulteration in herbal weight-loss products. This work contributes to the development of practical analytical tools for quality control and consumer safety monitoring.

Ključne riječi

AgNPs-ErGO nanocomposite; electrochemical sensor; sibutramine detection; linear sweep voltammetry; one-step electrochemical synthesis; herbal product adulteration

Hrčak ID:

350233

URI

https://hrcak.srce.hr/350233

Datum izdavanja:

5.7.2026.

Posjeta: 0 *