Original scientific paper

Modern Biotechnology of Phellinus baumii – From Fermentation to Proteomics

Hye Jin Hwang ; Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk 712–714, Korea
Sang Woo Kim ; Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk 712–714, Korea
Jong Won Yun ; Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk 712–714, Korea

Abstract

Phellinus baumii is a mushroom used as a folk medicine for a variety of human diseases in several Asian countries. Recently we have reported for the first time about the antidiabetic effect of the crude exopolysaccharides (EPS) produced from submerged mycelial culture of P. baumii in streptozotocin (STZ)-induced diabetic rats. The diabetic rats study revealed that orally administrated P. baumii EPS lowered the blood glucose levels and stimulated insulin excretion in diabetic rats, and consequently restored the functions of pancreas, liver, and kidney, suggesting that the EPS might be useful for the management of human diabetes mellitus. We undertook proteomic analyses for plasma, pancreas, liver, and kidney of the rats to search for novel biomarkers for monitoring diabetes before and after EPS treatments. In this article, we describe the production of EPS in submerged culture of P. baumii and studies of their hypoglycemic activity. We also explore the issue of proteomic analyses for mining biomarkers of diabetes.

Keywords

diabetes mellitus; exopolysaccharides; hypoglycemic effect; Phellinus baumii; proteome

Hrčak ID:

24178

URI

https://hrcak.srce.hr/24178

Publication date:

14.9.2007.

Article data in other languages: croatian

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