Original scientific paper

https://doi.org/10.20471/acc.2021.60.s1.11

Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study

Mario Laganović orcid.org/0000-0002-0240-4178 ; University Hospital Center Zagreb, Zagreb; School of Medicine, University of Zagreb, Zagreb
Ivica Horvatić ; Dubrava University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Ivan Bubić ; University Hospital Center Rijeka, Rijeka; School of Medicine, University of Rijeka, Rijeka
Mario Ilić ; Dubrovnik County Hospital, Dubrovnik
Bojana Maksimović ; Merkur University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Ana Kozmar ; University Hospital Center Zagreb, Zagreb
Ivana Vuković Brinar ; University Hospital Center Zagreb, Zagreb; School of Medicine, University of Zagreb, Zagreb
Matija Crnogorac ; Dubrava University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Marijana Živko ; University Hospital Center Zagreb, Zagreb; School of Medicine, J.J. Strossmayer University of Osijek
Margareta Fištrek ; University Hospital Center Zagreb, Zagreb
Željka Jureković ; Merkur University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Danica Galešić Ljubanović ; Dubrava University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Marijana Ćorić ; University Hospital Center Zagreb, Zagreb; School of Medicine, University of Zagreb, Zagreb
Stela Bulimbašić ; University Hospital Center Zagreb, Zagreb; School of Medicine, University of Zagreb, Zagreb
Krešimir Galešić ; University Hospital Center Zagreb, Zagreb; School of Medicine, University of Zagreb, Zagreb
Mladen Knotek ; Merkur University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb

Abstract

Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused
in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB). This study
aimed to evaluate the clinical course and outcomes of the patients with pMN regarding PLA2R-AB
status.
Patients and methods: 32 patients (21 males, 11 females) with renal biopsy-proven pMN were
included
in the study. PLA2R-AB (ELI SA method) and outcomes (defined according to KDIGO)
were evaluated after 21 and 64 months of follow-up in 28 patients.
Results: 19 patients had positive PLA2R-AB (>20 RU /ml) (59.3%), with median titer of 97
(21-1418 RU /ml). The rate of remission in low PLA2R-AB titer group (< 200 RU /ml) after 21
months was significantly higher than in high PLA2R-AB group (> 200 RU /ml) (90% vs. 50%,
p=0.045), and after 64 months the difference was not significant (80% vs. 50%, p=0.210). The relapse
rate after 64 months was higher in the high PLA2R-AB group (87% vs. 63%). Multivariant linear
regression found serum creatinine (ß=0.682, p<0.001) and PLA2R-AB (ß=0.527, p<0.001) as significant
predictors for kidney function at the end of follow-up.
Conclusion: higher titers of PLA2R-AB are related to worse kidney function outcome, higher
24-hour proteinuria, and a higher number of relapses in patients with pMN.

Keywords

Membranous nephropathy; M-type phospholipase A2 receptor; Autoantibodies; Glomerulonephritis

Hrčak ID:

260405

URI

https://hrcak.srce.hr/260405

Publication date:

1.1.2021.

Article data in other languages: croatian

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