Izvorni znanstveni članak
https://doi.org/10.20471/acc.2021.60.s1.11
Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study
Mario Laganović
orcid.org/0000-0002-0240-4178
; University Hospital Center Zagreb, Zagreb; School of Medicine, University of Zagreb, Zagreb
Ivica Horvatić
; Dubrava University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Ivan Bubić
; University Hospital Center Rijeka, Rijeka; School of Medicine, University of Rijeka, Rijeka
Mario Ilić
; Dubrovnik County Hospital, Dubrovnik
Bojana Maksimović
; Merkur University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Ana Kozmar
; University Hospital Center Zagreb, Zagreb
Ivana Vuković Brinar
; University Hospital Center Zagreb, Zagreb; School of Medicine, University of Zagreb, Zagreb
Matija Crnogorac
; Dubrava University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Marijana Živko
; University Hospital Center Zagreb, Zagreb; School of Medicine, J.J. Strossmayer University of Osijek
Margareta Fištrek
; University Hospital Center Zagreb, Zagreb
Željka Jureković
; Merkur University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Danica Galešić Ljubanović
; Dubrava University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Marijana Ćorić
; University Hospital Center Zagreb, Zagreb; School of Medicine, University of Zagreb, Zagreb
Stela Bulimbašić
; University Hospital Center Zagreb, Zagreb; School of Medicine, University of Zagreb, Zagreb
Krešimir Galešić
; University Hospital Center Zagreb, Zagreb; School of Medicine, University of Zagreb, Zagreb
Mladen Knotek
; Merkur University Hospital, Zagreb; School of Medicine, University of Zagreb, Zagreb
Sažetak
Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused
in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB). This study
aimed to evaluate the clinical course and outcomes of the patients with pMN regarding PLA2R-AB
status.
Patients and methods: 32 patients (21 males, 11 females) with renal biopsy-proven pMN were
included
in the study. PLA2R-AB (ELI SA method) and outcomes (defined according to KDIGO)
were evaluated after 21 and 64 months of follow-up in 28 patients.
Results: 19 patients had positive PLA2R-AB (>20 RU /ml) (59.3%), with median titer of 97
(21-1418 RU /ml). The rate of remission in low PLA2R-AB titer group (< 200 RU /ml) after 21
months was significantly higher than in high PLA2R-AB group (> 200 RU /ml) (90% vs. 50%,
p=0.045), and after 64 months the difference was not significant (80% vs. 50%, p=0.210). The relapse
rate after 64 months was higher in the high PLA2R-AB group (87% vs. 63%). Multivariant linear
regression found serum creatinine (ß=0.682, p<0.001) and PLA2R-AB (ß=0.527, p<0.001) as significant
predictors for kidney function at the end of follow-up.
Conclusion: higher titers of PLA2R-AB are related to worse kidney function outcome, higher
24-hour proteinuria, and a higher number of relapses in patients with pMN.
Ključne riječi
Membranous nephropathy; M-type phospholipase A2 receptor; Autoantibodies; Glomerulonephritis
Hrčak ID:
260405
URI
Datum izdavanja:
1.1.2021.
Posjeta: 850 *