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Acta clinica Croatica, Vol. 61. No. 2, 2022.

Original scientific paper

https://doi.org/10.20471/acc.2022.61.02.17

Pentraxin 3 Levels Correlate well with Disease Severity at Admission in COVID-19 Patients

Mehmet Emirhan Işık orcid id orcid.org/0000-0002-0699-8890 ; University of Health Sciences, Koşuyolu High Specialization Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey
Ramazan Korkusuz orcid id orcid.org/0000-0002-9988-9596 ; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey
Gülçin Erdal Şahingöz ; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Internal Medicine, Istanbul, Turkey
Arzu Cennet Işık ; University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Department of Internal Medicine, Istanbul, Turkey
Ali Karagöz orcid id orcid.org/0000-0002-0438-2021 ; University of Health Sciences, Koşuyolu High Specialization Research and Training Hospital, Department of Cardiology, Istanbul, Turkey
Nilgün Işıksaçan ; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Biochemistry, Istanbul, Turkey
Sevgi Kalkanlı Taş ; University of Health Sciences, Department of Immunology, Istanbul, Turkey
Kadriye Kart Yaşar orcid id orcid.org/0000-0003-2963-4894 ; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey;

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Abstract

Pentraxin 3 (PTX3), a long pentraxin, is not only released from dendritic cells and
neutrophils but also from epithelial and endothelial cells such as alveolar epithelium. Severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) initially activates the innate immune system, causing
a complex immune response. Clinical and experimental studies suggest that PTX3, a locally and
systemically secreted marker, can be used as a predictor of the severity and mortality in respiratory infections.
In the current study, serum PTX3 levels in patients hospitalized with COVID-19 were found
to be significantly increased at admission and showed significant association with the disease severity.

Keywords

COVID-19; Pentraxin 3; Innate immunity; C-reactive protein; SARS-CoV-2

Hrčak ID:

284793

URI

https://hrcak.srce.hr/284793

Publication date:

1.8.2022.

Article data in other languages: croatian

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