Acta clinica Croatica, Vol. 61. No. 2, 2022.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2022.61.02.17
Pentraxin 3 Levels Correlate well with Disease Severity at Admission in COVID-19 Patients
Mehmet Emirhan Işık
orcid.org/0000-0002-0699-8890
; University of Health Sciences, Koşuyolu High Specialization Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey
Ramazan Korkusuz
orcid.org/0000-0002-9988-9596
; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey
Gülçin Erdal Şahingöz
; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Internal Medicine, Istanbul, Turkey
Arzu Cennet Işık
; University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Department of Internal Medicine, Istanbul, Turkey
Ali Karagöz
orcid.org/0000-0002-0438-2021
; University of Health Sciences, Koşuyolu High Specialization Research and Training Hospital, Department of Cardiology, Istanbul, Turkey
Nilgün Işıksaçan
; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Biochemistry, Istanbul, Turkey
Sevgi Kalkanlı Taş
; University of Health Sciences, Department of Immunology, Istanbul, Turkey
Kadriye Kart Yaşar
orcid.org/0000-0003-2963-4894
; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey;
Sažetak
Pentraxin 3 (PTX3), a long pentraxin, is not only released from dendritic cells and
neutrophils but also from epithelial and endothelial cells such as alveolar epithelium. Severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) initially activates the innate immune system, causing
a complex immune response. Clinical and experimental studies suggest that PTX3, a locally and
systemically secreted marker, can be used as a predictor of the severity and mortality in respiratory infections.
In the current study, serum PTX3 levels in patients hospitalized with COVID-19 were found
to be significantly increased at admission and showed significant association with the disease severity.
Ključne riječi
COVID-19; Pentraxin 3; Innate immunity; C-reactive protein; SARS-CoV-2
Hrčak ID:
284793
URI
Datum izdavanja:
1.8.2022.
Posjeta: 953 *