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Libri Oncologici : Croatian Journal of Oncology, Vol. 50 No. 2-3, 2022.

Original scientific paper

https://doi.org/10.20471/LO.2022.50.02-03.12

Prognostic significance of preoperative computed hematological inflammatory parameters in patients with breast cancer

Karmela Ana Popović orcid id orcid.org/0000-0002-4966-7960 ; Department of Medical Biochemistry and Hematology, University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
Ljiljana Mayer ; Department of Medical Biochemistry in Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ivan Milas orcid id orcid.org/0000-0002-2083-1085 ; Division of Oncoplastic and Reconstructive Surgery, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mihaela Gaće ; Department of Medical Biochemistry in Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Milica Šoštarić orcid id orcid.org/0000-0003-1760-2852 ; Department of Medical Biochemistry in Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mario Šekerija orcid id orcid.org/0000-0001-7508-1501 ; Department for Malignant Diseases, Croatian Institute of Public Health, Zagreb, Croatia
Franjo Stručić orcid id orcid.org/0000-0003-1027-2782 ; Division of Oncology and Radiotherapy, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Donatella Verbanac orcid id orcid.org/0000-0002-9106-1604 ; Department of Medical Biochemistry and Hematology, University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia

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Abstract

Breast cancer is the most common malignant disease among women, constituting around a quarter of all cancers in women worldwide. This type of cancer is mainly affected by genetic, environmental, and lifestyle factors such as nutrition and physical activity.
A retrospective study including 192 women with breast cancer was performed for six years (from 2015 to 2021). We investigated the relationship between indirect hematological parameters, neutrophil-to lymphocyte ratio – NLR, plateletsto-lymphocyte ratio – PLR, systemic immune-inflammation index – SII and the treatment outcome. Additionally, we also followed the overall survival (OS) rate.
The obtained results report assessed parameters before and after surgical intervention. Of importance is to emphasize that at a cut-off value of 2.65 (P = 0.001) and 3.30 (P < 0.001), a decline in the NLR value was noticed after surgical removal of the breast cancer. The same decrease was observed for SII after surgery (P < 0.001). Through the study, SII has been shown to be a more relevant parameter compared to NLR and PLR. The study outcome recommends the cut-off value of 2.65 as the optimal for NLR in predicting the effectiveness and successfulness of the surgical procedure.

Keywords

breast cancer; neutrophil-to-lymphocyte ratio (NLR); platelets-to-lymphocyte ratio (PLR); systemic immune-inflammation index (SII); non-adjuvant treatment

Hrčak ID:

288514

URI

https://hrcak.srce.hr/288514

Publication date:

22.12.2022.

Article data in other languages: croatian

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