Original scientific paper
LUNG TRANSPLANTATION AT THE ZAGREB UNIVERSITY HOSPITAL CENTER, ZAGREB, CROATIA
TOMISLAV KOPJAR
orcid.org/0000-0002-4745-999X
; Department of Cardiac Surgery, Zagreb University Hospital Center, Zagreb, Croatia
FEĐA DŽUBUR
; Department of Lung Diseases, Zagreb University Hospital Center, Zagreb, Croatia
DORIAN HIRŠL
; Department of Thoracic Surgery, Zagreb University Hospital Center, Zagreb, Croatia
GORAN MADŽARAC
; Department of Thoracic Surgery, Zagreb University Hospital Center, Zagreb, Croatia
ZORAN JANEVSKI
; Department of Thoracic Surgery, Zagreb University Hospital Center, Zagreb, Croatia
JASNA ŠPIČEK MACAN
; Department of Anesthesiology, Zagreb University Hospital Center, Zagreb, Croatia
SANJA KONOSIĆ
; Department of Anesthesiology, Zagreb University Hospital Center, Zagreb, Croatia
HRVOJE GAŠPAROVIĆ
; Department of Cardiac Surgery, Zagreb University Hospital Center, Zagreb, Croatia
MIROSLAV SAMARŽIJA
; Department of Lung Diseases, Zagreb University Hospital Center, Zagreb, Croatia
Abstract
Objective: Lung transplantation has become a standard of care for patients with a variety of non-malignant end-stage lung diseases. The aim of the study was to report on the safety and feasibility of lung transplantation at the Zagreb University Hospital Center. Methods: In this single center retrospective observational study, all consecutive patients undergoing lung transplantation at the Zagreb University Hospital Center from April 2021 until December 2022 were included. The only inclusion criterion was surgery for lung transplantation. Patient demographic and operative characteristics were reported, as well as early outcomes, including 30-day mortality, hospital stay, intensive care unit stay, duration of mechanical ventilation, and incidence of primary graft dysfunction. The degree of primary graft dysfunction was graded based on the International Society for Heart and Lung Transplantation criteria at 72 hours after transplantation with grades 0 to 3. Results: During the 21-month study period, 19 patients were successfully transplanted. There was no 30-day mortality. There was one late death at 18 months after transplantation. Median in-hospital stay was 32 days, ranging from 21 to 62 days. Mean mechanical ventilation duration was 105±58 h and median of intensive care unit stay was 6 days, ranging from 4 to 15 days. Only two (11%) patients had the highest grade 3 primary graft dysfunction. Of the remaining patients, 16 (84%) had none (grade 0) and one (5%) patient had mild primary graft dysfunction (grade 1). Conclusion: Our results suggest that lung transplantation is safely performed at the Zagreb University Hospital Center. Initial results with no operative mortality are encouraging. Further follow-up and experience are needed to make inferences on long-term outcomes of our lung transplantation patients.
Keywords
ung transplantation, end-stage lung disease; extracorporeal membrane oxygenation; primary lung graft dysfunction; survival; operative mortality
Hrčak ID:
307174
URI
Publication date:
10.8.2023.
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