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LUNG TRANSPLANTATION AT THE ZAGREB UNIVERSITY HOSPITAL CENTER, ZAGREB, CROATIA

TOMISLAV KOPJAR orcid.org/0000-0002-4745-999X ; Klinika za kardiokirurgiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
FEĐA DŽUBUR ; Klinika za plućne bolesti, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
DORIAN HIRŠL ; Klinika za torakalnu kirurgiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
GORAN MADŽARAC ; Klinika za torakalnu kirurgiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
ZORAN JANEVSKI ; Klinika za torakalnu kirurgiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
JASNA ŠPIČEK MACAN ; Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
SANJA KONOSIĆ ; Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
HRVOJE GAŠPAROVIĆ ; Klinika za kardiokirurgiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
MIROSLAV SAMARŽIJA ; Klinika za plućne bolesti, Klinički bolnički centar Zagreb, Zagreb, Hrvatska

Sažetak

Objective: Lung transplantation has become a standard of care for patients with a variety of non-malignant end-stage lung diseases. The aim of the study was to report on the safety and feasibility of lung transplantation at the Zagreb University Hospital Center. Methods: In this single center retrospective observational study, all consecutive patients undergoing lung transplantation at the Zagreb University Hospital Center from April 2021 until December 2022 were included. The only inclusion criterion was surgery for lung transplantation. Patient demographic and operative characteristics were reported, as well as early outcomes, including 30-day mortality, hospital stay, intensive care unit stay, duration of mechanical ventilation, and incidence of primary graft dysfunction. The degree of primary graft dysfunction was graded based on the International Society for Heart and Lung Transplantation criteria at 72 hours after transplantation with grades 0 to 3. Results: During the 21-month study period, 19 patients were successfully transplanted. There was no 30-day mortality. There was one late death at 18 months after transplantation. Median in-hospital stay was 32 days, ranging from 21 to 62 days. Mean mechanical ventilation duration was 105±58 h and median of intensive care unit stay was 6 days, ranging from 4 to 15 days. Only two (11%) patients had the highest grade 3 primary graft dysfunction. Of the remaining patients, 16 (84%) had none (grade 0) and one (5%) patient had mild primary graft dysfunction (grade 1). Conclusion: Our results suggest that lung transplantation is safely performed at the Zagreb University Hospital Center. Initial results with no operative mortality are encouraging. Further follow-up and experience are needed to make inferences on long-term outcomes of our lung transplantation patients.

Ključne riječi

ung transplantation, end-stage lung disease; extracorporeal membrane oxygenation; primary lung graft dysfunction; survival; operative mortality

Hrčak ID:

307174

URI

https://hrcak.srce.hr/307174

Datum izdavanja:

10.8.2023.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.035 *