Short communication, Note

Antitumour Activity of Grifola frondosa Exopolysaccharides Produced by Submerged Fermentation Using Sugar Cane and Soy Molasses as Carbon Sources

Jacqueline Sugitani Chimilovski ; Bioprocess Engineering and Biotechnology Division, Centro Politécnico, Federal University of Paraná, 81531-990 Curitiba, Paraná, Brazil
Sascha Habu ; Bioprocess Engineering and Biotechnology Division, Centro Politécnico, Federal University of Paraná, 81531-990 Curitiba, Paraná, Brazil
Richard Fhillipy Bosqui Teixeira ; Bioprocess Engineering and Biotechnology Division, Centro Politécnico, Federal University of Paraná, 81531-990 Curitiba, Paraná, Brazil
Vanete Thomaz-Soccol ; Bioprocess Engineering and Biotechnology Division, Centro Politécnico, Federal University of Paraná, 81531-990 Curitiba, Paraná, Brazil
Miguel Daniel Noseda ; Department of Biochemistry and Molecular Biology, Centro Politécnico, Federal University of Paraná, 81531-990 Curitiba, Paraná, Brazil
Adriane Bianchi Pedroni Medeiros ; Bioprocess Engineering and Biotechnology Division, Centro Politécnico, Federal University of Paraná, 81531-990 Curitiba, Paraná, Brazil
Ashok Pandey ; Biotechnology Division, National Institute for Interdisciplinary Science and Technology (NIIST), CSIR, 695 019 Trivandrum, India
Carlos Ricardo Soccol ; Bioprocess Engineering and Biotechnology Division, Centro Politécnico, Federal University of Paraná, 81531-990 Curitiba, Paraná, Brazil

Abstract

Grifola frondosa is an edible Basidiomycete and produces exopolysaccharides (EPS) known for their antitumour activity. The objectives of this study are to produce exopolysaccharides in submerged fermentation using alternative carbon sources (sugar cane and soy molasses), and to evaluate their anti-proliferative activity against tumour cells. Exopolysaccharides were extracted by ethanol and tested against mice tumour cells, then characterized by gas chromatography. Carbon sources represent the major cost of the bioprocess, so a search for new alternatives such as agro-industrial residues is important to establish the viability on an industrial scale. Moreover, the data about the kinetics of the EPS production allow studying the optimization of the process.

Keywords

Grifola frondosa; kinetics; molasses; exopolysaccharides; antitumour activity; submerged culture

Hrčak ID:

71065

URI

https://hrcak.srce.hr/71065

Publication date:

10.8.2011.

Article data in other languages: croatian

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