Review article

https://doi.org/10.15255/KUI.2019.035

Application of Mathematical Modelling in Development of Enzymatic Cascade Reactions

Nevena Milčić orcid.org/0000-0003-0712-2417 ; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia
Morana Česnik ; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia
Martina Sudar orcid.org/0000-0002-6734-1024 ; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia
Zvjezdana Findrik Blažević orcid.org/0000-0002-5312-8951 ; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia

Abstract

Today, systems biocatalysis, i.e., the implementation of cascade reactions that mimic cellular metabolic pathways, is increasingly being used. Cascade reactions have numerous advantages over traditional chemical processes; however, in order to successfully optimize and transfer such complex systems to a larger, industrial scale, it is necessary to apply reaction engineering. This review paper provides examples of the successful application of mathematical modelling in development of enzymatic cascade reactions that demonstrate the importance and potential of this methodology.


This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords

reaction engineering; biocatalysis; modelling; optimization; multi-enzymatic systems

Hrčak ID:

225290

URI

https://hrcak.srce.hr/225290

Publication date:

7.10.2019.

Article data in other languages: croatian

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