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Review article

https://doi.org/10.21464/sp34206

Genome Editing and Selection Based on Genes Associated with Sports Athletic Performance – Some Bio-Ethical Issues

Matea Zajc Petranović orcid id orcid.org/0000-0002-8960-4446 ; Institute for Anthropological Research, Gajeva 32, HR–10000 Zagreb
Julija Erhardt ; University of Zagreb, Faculty of Science, Rooseveltov trg 6, HR–10000 Zagreb
Matija Mato Škerbić orcid id orcid.org/0000-0003-0006-4533 ; University of Zagreb, Faculty of Croatian Studies, Borongajska cesta 83d, HR–10000 Zagreb
Nataša Jermen ; The Miroslav Krleža Institute of Lexicography, Frankopanska 26, HR–10000 Zagreb
Petra Korać ; University of Zagreb, Faculty of Science, Horvatovac 102a, HR–10000 Zagreb


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Abstract

In 2003 the final results of the Human Genome Project revealed the details of our genome: a set of information about how human beings look, how we act, feel, think and develop. Soon after, other global collaborations such as the HapMap project and 1000 Genomes Project were conducted. Although the main focus was to investigate the variability in human populations and the possible connections of certain variations to different conditions and diseases, these projects also had a great impact on the understanding of the genetic influence on sports performance. In parallel, improved methods for gene analysis and gene editing were developed. Based on those methods, it became possible to detect candidate genes responsible for different performance phenotypes and develop protocols similar to gene therapies for performance enhancement in athletes. This review covers developments in genetics, the overview of candidate genes associated with athletic performance, and ethical dilemmas related to the modification of genome for sport performance enhancement.

Keywords

poboljšavanje, sportska uspješnost, sekvenciranje, genomsko preinačavanje, geni kandidati, etičke dileme

Hrčak ID:

232368

URI

https://hrcak.srce.hr/232368

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