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https://doi.org/10.17113/ftb.58.01.20.6351

Identifikacija bioaktivnih sastojaka iz ekstrakta lišća slaka (Ipomoea tuba) i njihov in vitro antiproliferacijski učinak na tumorske stanične linije MCF-7 i HeLa

Thirupati Chinna Venkateswarulu ; Department of Bio-Technology, Vignan’s Foundation for Science, Technology & Research (Deemed to be University), Vadlamudi-522213, Guntur, Andhra Pradesh, India
Gaddam Eswaraiah ; Department of Bio-Technology, Vignan’s Foundation for Science, Technology & Research (Deemed to be University), Vadlamudi-522213, Guntur, Andhra Pradesh, India
Srirama Krupanidhi ; Department of Bio-Technology, Vignan’s Foundation for Science, Technology & Research (Deemed to be University), Vadlamudi-522213, Guntur, Andhra Pradesh, India
Karlapudi Abraham Peele ; Department of Bio-Technology, Vignan’s Foundation for Science, Technology & Research (Deemed to be University), Vadlamudi-522213, Guntur, Andhra Pradesh, India
Indira Mikkili ; Department of Bio-Technology, Vignan’s Foundation for Science, Technology & Research (Deemed to be University), Vadlamudi-522213, Guntur, Andhra Pradesh, India
Alugunulla Venkata Narayana ; Department of Bio-Technology, Vignan’s Foundation for Science, Technology & Research (Deemed to be University), Vadlamudi-522213, Guntur, Andhra Pradesh, India
Bharath Kumar Ravuru ; School of Life Sciences, Rayalaseema University, Kurnool-518002, Andhra Pradesh, India
John Babu Dulla ; Department of Bio-Technology, Vignan’s Foundation for Science, Technology & Research (Deemed to be University), Vadlamudi-522213, Guntur, Andhra Pradesh, India
Ranga Rao Ambati ; Department of Bio-Technology, Vignan’s Foundation for Science, Technology & Research (Deemed to be University), Vadlamudi-522213, Guntur, Andhra Pradesh, India


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Abstract

Biljke mangrova sadržavaju širok raspon bioaktivnih sastojaka s farmakološkim svojstvima. U ovom su radu iz lišća slaka (Ipomoea tuba) pomoću metanola ekstrahirani fitokonstituenti, čiji je sastav određen metodom plinske kromatografije/masene spektrometrije (GC-MS), te je in vitro ispitan njihov antiproliferacijski učinak na tumorske stanične linije MCF-7 i HeLa. U ekstraktu lišća su pronađene fitokemikalije poput: behenične, α-linolenske i linolne kiseline, triterpenoida γ-sitosterola i terpenskih alkohola. Zatim je in vitro ispitan antiproliferacijski učinak ekstrakta na tumorske stanične linije i utvrđeno je da je došlo do smanjenja vijabilnosti stanične linije MCF-7 za 37,43 % i HeLa za 41,89 %. Zaključeno je da je ekstrakt lišća slaka dobiven primjenom metanola kao otapala učinkovit u zaštiti stanica od oksidacijskog stresa. Ovo je prvi izvještaj o in vitro citotoksičnom učinku ekstrakta lišća slaka na stanične linije MCF-7 i HeLa.

Keywords

biljke mangrova; Ipomoea tuba; bioaktivni sastojci; antiproliferacijski učinak

Hrčak ID:

237582

URI

https://hrcak.srce.hr/237582

Publication date:

28.4.2020.

Article data in other languages: english

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