Review article

https://doi.org/10.31895/hcptbn.15.3-4.9

Trends and challenges in influenza vaccine technology

Igor Slivac orcid.org/0000-0002-8344-1244 ; Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
Ena Buljubašić orcid.org/0000-0002-5719-9837 ; Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
Višnja Gaurina Srček orcid.org/0000-0001-6591-3810 ; Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
Marijan Logarušić orcid.org/0000-0002-6616-8813 ; Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia

Abstract

Influenza (flu) is a viral, contagious, respiratory disease that annually infects up to a billion people worldwide. It appears each year as a seasonal flu, but through history, it appeared as pandemic illness once in every several decades. Its harmful effects on human health and consequently to the society can be prevented by vaccination. The first approved influenza vaccine was made almost 80 years ago using embryonated hen eggs and the same technology is still in use for most available vaccines today. The development of cell biology and improvement of cell culture manufacturing techniques enabled the transition from conventional to novel, more efficient vaccine production methods. In this work we describe the epidemiology of influenza, influenza virus structure as well as current influenza vaccine manufacturing approaches. A brief overview of universal vaccine development and its urgency is discussed in the final section of the paper.

Keywords

biotechnology, influenza vaccine, influenza virus, flu, vaccination

Hrčak ID:

248383

URI

https://hrcak.srce.hr/248383

Publication date:

22.12.2020.

Article data in other languages: croatian

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