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Acta clinica Croatica, Vol. 59. No. 4., 2020.

Case report

https://doi.org/10.20471/acc.2020.59.04.25

Plućna fibroza izazvana oksaliplatinom: prikaz slučaja

Mirjana Pavlović orcid id orcid.org/0000-0002-9633-064X ; Sestre milosrdnice University Hospital Centre, University Hospital for Tumors, Department of Medical Oncology, Zagreb, Croatia
Robert Šeparović orcid id orcid.org/0000-0002-4002-2699 ; Sestre milosrdnice University Hospital Centre, University Hospital for Tumors, Department of Medical Oncology, Zagreb, Croatia
Tajana Silovski orcid id orcid.org/0000-0002-4699-5432 ; Sestre milosrdnice University Hospital Centre, University Hospital for Tumors, Department of Medical Oncology, Zagreb, Croatia
Ana Tečić Vuger orcid id orcid.org/0000-0003-2203-161X ; Sestre milosrdnice University Hospital Centre, University Hospital for Tumors, Department of Medical Oncology, Zagreb, Croatia
Andreja Jurić orcid id orcid.org/0000-0002-7539-2278 ; Sestre milosrdnice University Hospital Centre, University Hospital for Tumors, Department of Medical Oncology, Zagreb, Croatia

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Abstract

Oksaliplatin je dio standardnih kemoterapijskih protokola za liječenje kolorektalnog karcinoma. Plućna fibroza je ozbiljna,
ali rijetka nuspojava primjene oksaliplatina, koja je rezultirala smrću bolesnika u više od polovine prijavljenih slučajeva.
Točan patofiziološki mehanizam nastanka ove nuspojave još nije u potpunosti razjašnjen. Analiza prijavljenih slučajeva je
pokazala da su rana dijagnoza i rani početak liječenja kortikosteroidima od ključne važnosti za bolju prognozu. Ovdje prikazujemo
slučaj plućne fibroze uz primjenu oksaliplatina u bolesnika s ranim kolorektalnim karcinomom.

Keywords

Oksaliplatin; Karcinom kolona; Nuspojave; Plućna fibroza; Intersticijska plućna bolest

Hrčak ID:

255233

URI

https://hrcak.srce.hr/255233

Publication date:

1.12.2020.

Article data in other languages: english

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