Original scientific paper

https://doi.org/10.20471/acc.2022.61.02.09

Chronic Kidney Disease in Rural Population

Marija Domislović ; University of Zagreb School of Medicine, Zagreb, Croatia
Viktor Domislović ; Zagreb University Hospital Center, Zagreb, Croatia
Ranko Stevanović ; National Institute of Public Health, Zagreb, Croatia
Mirjana Fuček ; Zagreb University Hospital Center, Zagreb, Croatia
Živka Dika ; University of Zagreb School of Medicine, Zagreb, Croatia; Zagreb University Hospital Center, Zagreb, Croatia
Sandra Karanović ; University of Zagreb School of Medicine, Zagreb, Croatia; Zagreb University Hospital Center, Zagreb, Croatia
Jelena Kos ; Zagreb University Hospital Center, Zagreb, Croatia
Ana Jelaković ; Zagreb University Hospital Center, Zagreb, Croatia
Vedran Premužić ; Zagreb University Hospital Center, Zagreb, Croatia
Ninoslav Leko ; Dr. Josip Benčević General Hospital, Slavonski Brod, Croatia
Josipa Josipović ; Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ivan Brzić ; Municipality of Bebrina, Bebrina, Croatia
Tajana Željković Vrkić ; Zagreb University Hospital Center, Zagreb, Croatia
Krunoslav Capak ; National Institute of Public Health, Zagreb, Croatia
Bojan Jelaković ; University of Zagreb School of Medicine, Zagreb, Croatia; Zagreb University Hospital Center, Zagreb, Croatia

Abstract

The aims of the study were to provide data on chronic kidney disease (CKD) prevalence
in rural population and to analyze the association with cardiovascular risk factors and aging. A
random sample of 2193 farmers (1333 female (F) and 860 male (M), mean age 50.61±17.12) were
enrolled. Questionnaire and clinical examination were conducted. Participants provided a spot urine and
fasting blood sample. Estimated glomerular filtration rate (eGFR) was estimated using Chronic Kidney
Disease Epidemiology Collaboration (CKD-EPI) equation. Subjects were classified according to the
KDIGO guidelines. The overall prevalence of CKD (eGFR <60 mL/min/1.73 m2) was 8.83% (F vs. M
9.9% vs. 6.3%; p<0.001). Albuminuria (albumin-to-creatinine ratio >30 mg/g) was found in 8.45% (F
vs. M p>0.05). Sharp increase in CKD prevalence was found to begin after the sixth decade (29.44% in
subjects older than 65 years; F vs. M 30.9% vs. 26.8%; p<0.01). The strongest predictor factors for CKD
were age >65 years (OR 22.12), hypertension (OR 6.53), albuminuria (OR 5.71), fasting blood glucose
>7 mmol/L (OR 5.49), diabetes (OR 3.07), abdominal obesity (OR 2.05) and non-smoking (OR 0.41).
In multivariate analysis, age (OR 1.13), female gender (OR 0.60) and diabetes (OR 1.75) were the independent
predictor factors for CKD. In conclusion, CKD prevalence is high in rural population, being
higher in women than in men. In both genders, eGFR significantly decreased with aging. Aging is a
significant independent predictor of CKD.

Keywords

Chronic kidney disease; Prevalence; Aging; Albuminuria; Epidemiology

Hrčak ID:

284708

URI

https://hrcak.srce.hr/284708

Publication date:

1.8.2022.

Article data in other languages: croatian

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