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Acta clinica Croatica, Vol. 61. No. 2, 2022.

Original scientific paper

https://doi.org/10.20471/acc.2022.61.02.17

Razine pentraksina 3 dobro su povezane s težinom bolesti kod prijma u bolesnika s COVID-19

Mehmet Emirhan Işık orcid id orcid.org/0000-0002-0699-8890 ; University of Health Sciences, Koşuyolu High Specialization Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey
Ramazan Korkusuz orcid id orcid.org/0000-0002-9988-9596 ; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey
Gülçin Erdal Şahingöz ; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Internal Medicine, Istanbul, Turkey
Arzu Cennet Işık ; University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Department of Internal Medicine, Istanbul, Turkey
Ali Karagöz orcid id orcid.org/0000-0002-0438-2021 ; University of Health Sciences, Koşuyolu High Specialization Research and Training Hospital, Department of Cardiology, Istanbul, Turkey
Nilgün Işıksaçan ; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Biochemistry, Istanbul, Turkey
Sevgi Kalkanlı Taş ; University of Health Sciences, Department of Immunology, Istanbul, Turkey
Kadriye Kart Yaşar orcid id orcid.org/0000-0003-2963-4894 ; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey;

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Abstract

Pentraksin 3 (PTX3), dugi pentraksin, ne oslobađa se samo iz dendritičnih stanica i neutrofila, nego i iz epitelnih i
endotelnih stanica poput alveolarnog epitela. Teški akutni respiracijski sindrom koronavirus-2 (SARS-CoV-2) u početku
aktivira urođeni imuni sustav uzrokujući složen imuni odgovor. Klinička i eksperimentalna istraživanja ukazuju na to da se
PTX3, lokalno i sistemski izlučeni biljeg, može koristiti kao prediktor težine i smrtnosti kod respiracijskih infekcija. U ovom
istraživanju utvrđeno je da su razine PTX3 u serumu bolesnika hospitaliziranih s COVID-19 bile značajno povišene kod
prijma i značajno povezane s težinom bolesti.

Keywords

COVID-19; Pentraksin 3; Urođeni imunitet; C-reaktivni protein; SARS-CoV-2

Hrčak ID:

284793

URI

https://hrcak.srce.hr/284793

Publication date:

1.8.2022.

Article data in other languages: english

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