Original scientific paper
https://doi.org/10.15255/KUI.2023.005
Ru(III) Complexes and Their Ligands Derived from Salicylaldehyde and Halogenated Anilines: Synthesis, Characterisation, and Antioxidant Activity
Nevzeta Ljubijankić
orcid.org/0000-0002-7421-4592
; Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Enis Šuta
orcid.org/0000-0002-2561-3001
; Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Anela Ćatić
; Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Sabina Begić
orcid.org/0000-0002-3523-8268
; Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Sead Ljubijankić
orcid.org/0000-0002-7421-4592
; Faculty of Health Studies, University of Bihać, Nositelja hrvatskog trolista 4, Bihać, Bosnia and Herzegovina
Saida Ibragić
orcid.org/0000-0002-0201-4057
; Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Abstract
This work aimed to describe the synthesis and characterisation of two anionic Ru(III) complexes of the general formula Na[RuCl2(N-4-Cl-Ph-salim)2] and Na[RuCl2(N-3-Br-Ph-salim)2, their associated ligands, and determine their antioxidant activity. The ligands N-4-Cl-phenylsalicylidenimine (N-4-Cl-Ph-salimH, HLa) and N-3-Br-phenylsalicylidenimine (N-3-Br-Ph-salimH, HLb), Schiff bases, were synthesised from salicylaldehyde and chloroaniline or bromoaniline. The compounds were characterised using IR spectroscopy and ESI ToF mass spectrometry. The following was confirmed: coordination of ligands on the Ru(III) centre, the molecular formulas, and the corresponding M– ions: [C26H18N2O2Cl4Ru]–26H18N2O2Cl2Br2Ru]– ion, (m/z: 719.8283). The antioxidant activity was determined by the ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. In contrast to the ligands, both complexes proved to be strong scavengers of the ABTS and DPPH radicals with IC50 (half maximal inhibitory concentration) values comparable to those of Trolox. As such, they present valuable candidates for further research related to their biological properties.
Keywords
Ru(III) complexes; Schiff bases; IR spectroscopy; ESI ToF mass spectrometry; antioxidant activity
Hrčak ID:
304923
URI
Publication date:
13.7.2023.
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