Acta clinica Croatica, Vol. 64. No. 3, 2025.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2025.64.03.17
Patterns of Neutrophil to Lymphocyte Ratio Change in two Inflammatory Rheumatic Diseases: Systemic Lupus Erythematosus and Rheumatoid Arthritis
Antica Mihaliček
orcid.org/0000-0001-8010-1984
; Dubrava University Hospital, University of Zagreb, School of Medicine, Department of Internal Medicine, Department of Clinical Immunology, Allergology and Rheumatology, Zagreb, Croatia
*
Branimir Anić
orcid.org/0000-0003-4940-0577
; University Hospital Centre Zagreb, University of Zagreb, School of Medicine, Department of Internal Medicine, Division of Clinical Immunology and Rheumatology, Zagreb, Croati
Ivan Marković
; Special Hospital for Pulmonary Diseases, Zagreb, Croatia
Ivan Padjen
; University Hospital Centre Zagreb, University of Zagreb, School of Medicine, Department of Internal Medicine, Division of Clinical Immunology and Rheumatology, Zagreb, Croati
Jadranka Morović-Vergles
orcid.org/0000-0002-2672-8871
; Dubrava University Hospital, University of Zagreb, School of Medicine, Department of Internal Medicine, Department of Clinical Immunology, Allergology and Rheumatology, Zagreb, Croatia
* Dopisni autor.
Sažetak
A high neutrophil to lymphocyte ratio (NLR) is a potential marker of systemic
inflammation and predictor of worse outcomes in numerous diseases, but with no report on the pattern
of change in NLR (changes in absolute neutrophil and lymphocyte counts with corresponding changes
in NLR). Aim: to investigate the pattern of change in NLR in systemic inflammation. Systemic lupus
erythematosus (SLE) and rheumatoid arthritis (RA) were taken as examples of systemic inflammatory
disorders. We included 146 SLE patients and 181 RA patients in this retrospective study. The following
data were collected: leukocyte, neutrophil and lymphocyte counts and CRP for all patients; C3, C4,
hemoglobin concentration and SLEDAI for SLE; swollen and tender joint counts and DAS28CRP for
RA. NLR was calculated from absolute neutrophil and lymphocyte counts in peripheral blood and correlated
with relevant markers of disease activity. In both diseases, NLR positively correlated with disease
activity, but with different patterns: in SLE due to a decreased lymphocyte count without concomitant
change in the neutrophil count and in RA due to an elevated neutrophil count without concomitant
change in the lymphocyte count. When investigating NLR, it is important to also evaluate the pattern
of change in NLR for its right interpretation and understanding in the context of disease pathogenesis.
Ključne riječi
systemic lupus erythematosus; rheumatoid arthritis; biomarkers; systemic inflammation; neutrophil to lymphocyte ratio
Hrčak ID:
342943
URI
Datum izdavanja:
30.9.2025.
Posjeta: 471 *