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Journal of Electrochemical Science and Engineering, Vol. 16 , 2026.

Izvorni znanstveni članak

https://doi.org/10.5599/jese.3001

Determination of acetaminophen and theophylline in drug samples by electrochemical method using Fe/MCM-41 modified electrode

Huynh Thanh Danh ; University of Sciences, Hue University, Vietnam and Giong Rieng High School, An Giang province, Vietnam
Nguyen Chi Bao ; Department of Science, Technology and International Relations, Hue University, Vietnam
Pham Thi Huyen Thoa ; Department of Natural Sciences & Technology, Tay Nguyen University, Vietnam
Nguyen Quang Man ; University of Medicine and Pharmacy, Hue University, Vietnam
Pham Dinh Du ; Thu Dau Mot University, Vietnam
Dinh Quang Khieu orcid id orcid.org/0000-0003-3473-6377 ; University of Sciences, Hue University, Vietnam *

* Dopisni autor.

Puni tekst: engleski pdf 458 Kb

preuzimanja: 96

citiraj

Sažetak

In this study, we developed an electrochemical sensor based on an Fe/MCM-41 modified electrode for the simultaneous analysis of acetaminophen (AT) and theophylline (TP). The Fe/MCM-41 material was produced from diatomite silica and ferric chloride salts via a hydrothermal method. The synthesized material was characterized by XRD, SEM, TEM, EDX mapping, and nitrogen adsorption-desorption isotherms. Results showed that the Fe/MCM-41 maintained its mesoporous structure, high surface area, and uniform dispersion of Fe ions. Electrochemical tests revealed that the Fe/MCM-41 electrode exhibits superior electrocatalytic activity and higher current responses for both analytes than the bare electrode. The two oxidation peaks of AT and TP were distinctly separated, enabling simultaneous quantification of drugs with high selectivity. The peak current increased linearly with AT and TP concentrations from 0.50 to 14.15 µM, with detection limits of 0.430 and 0.350 µM, respectively. Notably, the sensor was successfully used to analyze pharmaceutical formulations containing one or both active substances, with satisfactory recoveries. The results confirm that the Fe/MCM-41 electrode is a promising sensing platform for the simultaneous analysis of AT and TP, opening new possibilities for pharmaceutical testing.

Ključne riječi

Electrochemical sensor; modified glassy carbon electrode; mesoporous silica; doped iron; simultaneous drug analysis; real samples

Hrčak ID:

344850

URI

https://hrcak.srce.hr/344850

Datum izdavanja:

23.2.2026.

Posjeta: 230 *