Infektološki glasnik, Vol. 25 No. 4, 2005.
Izvorni znanstveni članak
Specific IgG decline after successful treatment of Helicobacter pylori infection according to treatment protocol with azithromycin
M.V. Vukadinović
C. Prohaska Potočmik
B. Šeni
Sažetak
As no treatment protocol for Helicobacter pylori (HP) eradication described to date, has a 100 % success rate, treatment monitoring is necessary. The ELISA specific IgG-serology is simple, accurate, safe, quick, relatively inexpensive and generally available technique. The aim of this study was to monitor the serology pattern in seropositive patients after successful eradication of HP with triple therapy. Characteristics of 90 treated patients, mean age 50 (16–79), on short-term serological monitoring are presented. The study group involved 52 patients with duodenal ulcer, 9 with gastric ulcer and 29 patients with gastritis but without ulcer. With Pyloriset EIA-G (Orion, Finland) immunoassay, anti-HP IgG-antibody titres were estimated. The pretreatment values varied between 280 and 11 875 (mean 2808) with cut-off level of 280 ±20. After treatment in every follow-up specimen IgG-levels declined gradually. The mean percentage of anti-HP IgG--decline in the group as a whole, if measured 2, 4, 6 and 12 months after treatment, was 56, 68, 75 and 87 respectively. During the first year of monitoring after treatment, all patients with pretreatment IgG-level less than 1200 (low titres) became seronegative. Decrease in the titre at 4 (40 %) or 6 (50 %) months after the last dose of antibiotics, can be used as a marker for HP-eradication.
Ključne riječi
Helicobacter pylori infection; serology; monitoring after treatment
Hrčak ID:
17898
URI
Datum izdavanja:
8.12.2005.
Posjeta: 4.106 *