Pregledni rad
THE USE OF VITAMIN D IN ASSISTED REPRODUCTIVE TECHNOLOGY PROCEDURES (ART) - CAN THE OCCURRENCE OF BREAST CANCER BE REDUCED?
Marija Dundović
orcid.org/0000-0003-2424-6518
; Clinical hospital centre Osijek, Department for medically assisted reproduction, J. Huttlera 4, 31000 Osijek, Croatia
Ines Banjari
orcid.org/0000-0002-8680-5007
; Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology Osijek, Department of Food and Nutrition Research, F. Kuhača 18, 31000 Osijek, Croatia
Lara Marcijuš
orcid.org/0000-0002-4748-1142
; Clinical hospital centre Osijek, Department for medically assisted reproduction, J. Huttlera 4, 31000 Osijek, Croatia
Sažetak
Introduction: Vitamin D has crucial biological activity and antioxidative function involved in human reproduction. Lots of infertility patients worldwide have their children through assisted reproductive technology. Beside endogenous synthesis, it is possible and important to supplement vitamin D with diet. Vitamin D insufficiency is strongly connected with severe diseases, cancers, infertility. Studies have reported vitamin D insufficiency in up to 75% of women with diagnosed breast cancer and improvements in survival after diagnosis in women with higher level of vitamin D.
Aim: The purpose of this narrative review was to elucidate the role of vitamin D in assisted reproductive technology (ART) procedures, prevention and reduction of breast cancer incidence providing current evidence from human studies.
Materials and methods: The Medline database was searched using keywords vitamin D, breast cancer, fertility, supplementation, in vitro fertilization. The search was made as of April 10, 2023.
Results and discussion: Majority of papers analysed show that vitamin D is important in achieving good quality embryos in procedures of medically assisted reproduction and through effects that are noticeable in endometrium vitamin D supplementation facilitates successful implantation of embryos. Research also shows that there is some elevated risk in developing breast cancer after those procedures, but some papers also show that there is no notable risk, so the results are inconclusive. We found that there is a general agreement that normal serum concentrations of vitamin D acts oncoprotective against breast cancer and may facilitate treatment on already developed cancer.
Conclusion: For women with elevated risk for breast cancer, supplementation with vitamin D after medically assisted reproduction seem to have protective effect.
Ključne riječi
vitamin D; breast cancer; fertility; supplementation; in vitro fertilization
Hrčak ID:
306282
URI
Datum izdavanja:
19.7.2023.
Posjeta: 542 *