Original scientific paper
https://doi.org/https://doi.org/10.5599/jese.3475
Bismuth-infused manganese molybdate nanostructures: a robust electrochemical platform for ultrasensitive uric acid detection
Chandraju Siddegowda Chidan Kumar
; Department of Basic Science, Vidya Vikas Institute of Engineering & Technology, Visvesvaraya Technological University, Inida
*
Kuppahalli Sudarshan Mahesh Lohith
; Department of Physics, ATME College of Engineering, Karnataka, India
Mudaganduru Nagaraja Ramachandra
; Department of Physics, ATME College of Engineering, Karnataka, India
Mezna Saleh Altowyan
; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Saudi Arabia
Payyanur Sumesh
; Department of Basic Science, Vidya Vikas Institute of Engineering & Technology, Visvesvaraya Technological University, Inida
Yarehalli Honnappa Pavithra
; Department of Studies and Research in Chemistry, Tumkur University, Tumkur 572103, India
Siddegowda Chandraju
; Department of Chemistry, Sir MVPG Center, Tubinakere, Mandya University, Karnataka, India
* Corresponding author.
Abstract
Sensitive and real-time monitoring of uric acid (UA) is essential for the effective management of metabolic disorders such as hyperuricemia and Lesch-Nyhan syndrome. Herein, MnMoO4 (MMO) and bismuth-doped MnMoO4 (BMMO) nanoparticles (NPs) were synthesized via a combustion method and employed to fabricate MMO-ME and BMMO-ME electrochemical sensors. Bi3+ incorporation was associated with lattice distortion and improved electrochemical charge-transfer characteristics, as evidenced by the electrochemical measurements. Electrochemical studies revealed a diffusion-controlled, proton-coupled UA oxidation process with optimal response at physiological pH (7.0), while NP loading optimization identified 4 mg as the ideal composition. Compared to MMO-ME, the BMMO-ME electrode exhibited higher anodic current and lower peak-to-peak separation, and faster electron-transfer kinetics due to the synergistic bimetallic effect. Differential pulse voltammetry enabled ultrasensitive UA detection over a wide linear range (10 to 60 nM) with low detection limits of 5.0 (MMO-ME) and 4.5 nM (BMMO-ME). Both sensors demonstrated excellent stability, repeatability and reproducibility (RSD < 2 %), while BMMO-ME showed superior resistance to surface fouling. Accurate UA recovery (98 to 103 %) from tap water confirmed practical applicability. Overall, this work highlights Bi-induced defect engineering as an effective strategy to activate MMO and establishes BMMO-ME as a robust, sensitive, and reliable platform for real-time UA biosensing.
Keywords
MnMoO4 nanoparticles; solution combustion; carbon paste electrode; differential pulse voltammetry; electrochemical sensing
Hrčak ID:
351289
URI
Publication date:
23.8.2026.
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