Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2025.66.352
The onset inflammatory parameters and the Cobb angle in adolescent idiopathic scoliosis: a case-control study
Gülseren Demir Karakılıç
; Yozgat City Hospital, Yozgat, Turkey
*
Esra Şahingöz Bakırcı
; Department of Physical Medicine and Rehabilitation, Yozgat Bozok University, Yozgat, Turkey
* Dopisni autor.
Sažetak
Aim To investigate the association between early in
flammatory markers: neutrophil/lymphocyte ratio (NLR),
monocyte/lymphocyte ratio (MLR), platelet/lymphocyte
ratio (PLR), and C-reactive protein/albumin ratio (CAR) and
the Cobb angle in adolescent idiopathic scoliosis (AIS).
Methods This multicenter case-control study (2017-2024)
enrolled 419 patients with AIS (Cobb angle >10°) and 381
age- and sex-matched controls (Cobb angle 0°). We col
lected demographic data, curve characteristics, and labo
ratory parameters (white blood cells [WBC], NLR, MLR, PLR,
and CAR) at the time of initial diagnosis, before treatment
initiation or infection. The Cobb angle was measured by
two independent radiologists blinded to clinical data.
Results Compared with controls, AIS patients had signifi
cantly higher WBC, neutrophil, lymphocyte, and monocyte
counts, CRP, NLR, and CAR, and lower platelets, PLR, and
calcium levels (all P < 0.05). CAR and NLR values increased
with greater Cobb angle. In contrast, mean platelet volume
did not differ between the groups.
Conclusion This is the first study to evaluate CAR in AIS,
demonstrating its significant association with the Cobb
angle, alongside NLR and MLR. As inexpensive and read
ily available markers, CAR and NLR may help in diagnosing
AIS, but their role in risk stratification and disease monitor
ing requires confirmation in future prospective studies.
Ključne riječi
Hrčak ID:
352549
URI
Datum izdavanja:
22.10.2025.
Posjeta: 0 *