Socijalna psihijatrija, Vol. 54 No. 2, 2026.
Sažetak sa skupa
https://doi.org/10.24869/spsih.2026.242
Association of Posttraumatic Stress Disorder, the Gut Microbiome, and Cardiometabolic Risk Among Croatian War Veterans
Leon Serdarević
; Klinički bolnički centar Split, Spinčićeva 1, 21000 Split, Hrvatska
*
Dolores Britvić
; Klinički bolnički centar Split, Spinčićeva 1, 21000 Split, Hrvatska; Medicinski fakultet, Sveučilište u Splitu, Šoltanska 2A, 21000 Split, Hrvatska
Joško Božić
; Medicinski fakultet, Sveučilište u Splitu, Šoltanska 2A, 21000 Split, Hrvatska
Roko Šantić
; Medicinski fakultet, Sveučilište u Splitu, Šoltanska 2A, 21000 Split, Hrvatska
Nikola Pavlović
; Medicinski fakultet, Sveučilište u Splitu, Šoltanska 2A, 21000 Split, Hrvatska
Ivana Irma Lerotić
; Klinički bolnički centar Split, Spinčićeva 1, 21000 Split, Hrvatska
Ivica Šamanić
; Prirodoslovno-matematički fakultet, Sveučilište u Splitu, Ruđera Boškovića 33, 21000 Split, Hrvatska
Tina Tičinović Kurir
; Klinički bolnički centar Split, Spinčićeva 1, 21000 Split, Hrvatska; Medicinski fakultet, Sveučilište u Splitu, Šoltanska 2A, 21000 Split, Hrvatska
* Dopisni autor.
Sažetak
Aim of the study: To examine the composition of
the gut microbiome and its association with cardiovascular
risk in war veterans with post-traumatic
stress disorder (PTSD) and type 2 diabetes
mellitus (T2DM). Materials and methods: The
study will include war veterans diagnosed with
PTSD and T2DM, as well as war veterans diagnosed
with PTSD without T2DM as a control
group. Validated questionnaires on adherence
to the Mediterranean diet (MDSS) will be administered,
psychological stress will be assessed
using the CAPS and ITQ questionnaires, anthropometric
parameters and body composition will
be measured, and laboratory parameters will be analyzed. Cardiovascular risk parameters will be
determined, including AGEs (advanced glycation
end-products), ABI (ankle-brachial index), and
serum markers of endothelial dysfunction. From
stool samples, 16S rRNA gene sequencing using
NGS technology and WGS (shotgun whole-genome
sequencing) analyses will be performed to
assess the composition and functional potential
of the gut microbiome in the study groups. Statistical
analysis: Multivariate analysis will enable
a comprehensive approach to identifying shared
genetic variants of the gut microbiome and potential
functional pathways associated with PTSD
and T2DM. A machine learning model will also
be developed to predict type 2 diabetes and cardiovascular
risk based on gut microbiome composition,
dietary habits, and level of psychological
stress. Results: It is hypothesized that chronic
psychological stress alters the composition of the
gut microbiome and increases cardiovascular risk
in individuals with PTSD, which would represent
an important scientific contribution. Analysis of
the gut microbiome, anthropometric parameters,
body composition, laboratory parameters, and
cardiovascular risk indicators could contribute
to a better understanding of the role of chronic
psychological stress in the pathogenesis of T2DM
and increased cardiovascular risk in war veterans.
Conclusion: A comprehensive analysis of the composition
and functional role of the gut microbiome
may contribute to a better understanding
of its role in diabetes and cardiovascular risk in
patients with PTSD and open up possibilities for
personalized microbiome-targeted therapeutic
approaches aimed at improving care and quality
of life in patients with PTSD.
Ključne riječi
Hrčak ID:
352906
URI
Datum izdavanja:
15.6.2026.
Posjeta: 0 *