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Kemija u industriji : Časopis kemičara i kemijskih inženjera Hrvatske, Vol. 61 No. 1, 2012.

Pregledni rad

II. Organometallic and Bioorganometallic Chemistry - Ferrocene Amino Acids

V. Rapić ; Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
L. Barišić ; Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia

Puni tekst: hrvatski, pdf (2 MB) str. 9-29 preuzimanja: 494* citiraj
APA 6th Edition
Rapić, V. i Barišić, L. (2012). II. Organometalna i bioorganometalna kemija - ferocenske aminokiseline. Kemija u industriji, 61 (1), 9-29. Preuzeto s https://hrcak.srce.hr/75971
MLA 8th Edition
Rapić, V. i L. Barišić. "II. Organometalna i bioorganometalna kemija - ferocenske aminokiseline." Kemija u industriji, vol. 61, br. 1, 2012, str. 9-29. https://hrcak.srce.hr/75971. Citirano 24.03.2019.
Chicago 17th Edition
Rapić, V. i L. Barišić. "II. Organometalna i bioorganometalna kemija - ferocenske aminokiseline." Kemija u industriji 61, br. 1 (2012): 9-29. https://hrcak.srce.hr/75971
Harvard
Rapić, V., i Barišić, L. (2012). 'II. Organometalna i bioorganometalna kemija - ferocenske aminokiseline', Kemija u industriji, 61(1), str. 9-29. Preuzeto s: https://hrcak.srce.hr/75971 (Datum pristupa: 24.03.2019.)
Vancouver
Rapić V, Barišić L. II. Organometalna i bioorganometalna kemija - ferocenske aminokiseline. Kemija u industriji [Internet]. 2012 [pristupljeno 24.03.2019.];61(1):9-29. Dostupno na: https://hrcak.srce.hr/75971
IEEE
V. Rapić i L. Barišić, "II. Organometalna i bioorganometalna kemija - ferocenske aminokiseline", Kemija u industriji, vol.61, br. 1, str. 9-29, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/75971. [Citirano: 24.03.2019.]

Sažetak
This article is the second part of a series dealing with organometallic and bioorganometallic chemistry. In the first part of this series a short review on the history and development of these disciplines was given, emphasizing the importance and scope of bioorganometallic chemistry as a new field dealing with conjugates of organometallics and biomolecules (DNA, PNA, amino acids, peptides...). From the variety of biorganometallics, syntheses and properties of simple conjugates of ferrocene with natural amino acids/peptides were elaborated inter alia.

This material is the basis for the second part in which ferrocene amino acids are described. The introduction presents nonproteinogenic alicyclic and aromatic amino acids as the models for the title compounds. Naturally occurring amino acids labelled with ferrocene moiety mostly retain properties of the biomolecules included. Contrary to these ω-ferrocenylamino acids, one could imagine specific amino acids with inserted ferrocene core belonging to either homo- or heterodisubstituted type. The central part of this article is devoted to our investigations of the second type - H2N-(CH2)m-Fn-(CH2)n-COOH. The general rational procedure for synthesis of these compounds and of their N- and/or C-protected derivatives via the azide intermediates N3-CO-(CH2)m- Fn-(CH2)n-COOMe has been described. In the solid state derivatives of ferrocene amino acids contain intermolecular hydrogen bonds giving dimeric structures, three-dimensional networks or endless helical chains. The solutions of homologues Ac-NH-(CH2)m-Fn-(CH2)n-COOMe in nonpolar solvents are dominated by open form conformers. Compounds containing 2–3 ferrocene cores connected by amide, imide and oxalamide spacers were prepared by oligomerization of 1'-aminoferrocene-1-carboxylic acid (Fca) or by its condensation with the appropriate reagents. Similar to natural amino acids, ferrocene amino acids are water-soluble substances with high melting points, insoluble in organic solvents.

Ključne riječi
Bioorganometallic Chemistry; reactions; structure

Hrčak ID: 75971

URI
https://hrcak.srce.hr/75971

[hrvatski]

Posjeta: 768 *