Izvorni znanstveni članak
https://doi.org/10.15255/KUI.2019.007
Electrospun Polycaprolactone for Controlled Drug Delivery
Emi Govorčin Bajsić
; Fakultet kemijskog inženjerstva i tehnologije, Sveučilište u Zagrebu, Marulićev trg 19, 10 000 Zagreb
Emilija Zdraveva
orcid.org/0000-0003-2845-8630
; Fakultet kemijskog inženjerstva i tehnologije, Sveučilište u Zagrebu, Marulićev trg 19, 10 000 Zagreb
Budimir Mijović
; Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet, Hrvatska
Tamara Holjevac Grgurić
; Sveučilište u Zagrebu, Metalurški fakultet Sisak, Hrvatska
Mirna Tominac Trcin
; Sveučilišna bolnica Sestre Milosrdnice, Banka tkiva, Klinika za traumatologiju, Hrvatska
Tea Zubin Ferri
; Centar za istraživanje materijala Istarske županije, Hrvatska
Sažetak
Tissue engineering is a good alternative for the development of tissue or potential organs from the patient’s own cell material in order to reduce the problem of organ transplant deficiency. Electrospun materials are good candidates for use in biomedicine, as scaffolds for tissue cells culture. Additionally, these scaffolds can provide controlled drug release in tissue regenerative therapies. In this paper, controlled release of antibiotic Cefuroxim (CFU), which is used for ocular tissue therapy, was investigated. The polycaprolactone scaffolds were prepared by electrospinning with the addition of CFU in the amount of 1, 2, 5, and 10 wt %. The successful antibiotic capsulation was confirmed by the new characteristic peaks appearing in the FTIR spectra of the electrospun blends. With the addition of antibiotic and increase in its concentration, fibres with more uniform morphology and less deformations along the fibres length were obtained. The release of antibiotic from PCL scaffolds was determined by UV–VIS spectrophotometer. Obtained was an increase in absorption of antibiotics with time and with increased drug concentration in the scaffolds.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ključne riječi
electrospinning; polycaprolactone; Cefuroxime; scaffolds; tissue engineering
Hrčak ID:
225273
URI
Datum izdavanja:
7.10.2019.
Posjeta: 975 *