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Identical and Nonidentical Twin Drugs

M. Huzjak ; Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
Z. Rajić ; Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
B. Zorc ; Faculty of Pharmacy and Biochemistry, Zagreb, Croatia

Puni tekst: hrvatski, pdf (544 KB) str. 511-519 preuzimanja: 416* citiraj
APA 6th Edition
Huzjak, M., Rajić, Z. i Zorc, B. (2008). Dvojni lijekovi s identičnim i neidentičnim podjedinicama. Kemija u industriji, 57 (11), 511-519. Preuzeto s https://hrcak.srce.hr/29417
MLA 8th Edition
Huzjak, M., et al. "Dvojni lijekovi s identičnim i neidentičnim podjedinicama." Kemija u industriji, vol. 57, br. 11, 2008, str. 511-519. https://hrcak.srce.hr/29417. Citirano 18.10.2019.
Chicago 17th Edition
Huzjak, M., Z. Rajić i B. Zorc. "Dvojni lijekovi s identičnim i neidentičnim podjedinicama." Kemija u industriji 57, br. 11 (2008): 511-519. https://hrcak.srce.hr/29417
Harvard
Huzjak, M., Rajić, Z., i Zorc, B. (2008). 'Dvojni lijekovi s identičnim i neidentičnim podjedinicama', Kemija u industriji, 57(11), str. 511-519. Preuzeto s: https://hrcak.srce.hr/29417 (Datum pristupa: 18.10.2019.)
Vancouver
Huzjak M, Rajić Z, Zorc B. Dvojni lijekovi s identičnim i neidentičnim podjedinicama. Kemija u industriji [Internet]. 2008 [pristupljeno 18.10.2019.];57(11):511-519. Dostupno na: https://hrcak.srce.hr/29417
IEEE
M. Huzjak, Z. Rajić i B. Zorc, "Dvojni lijekovi s identičnim i neidentičnim podjedinicama", Kemija u industriji, vol.57, br. 11, str. 511-519, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/29417. [Citirano: 18.10.2019.]

Sažetak
Twin drugs contain two pharmacophoric groups combined covalently in a single molecule. Pharmacophoric groups can be identical moieties (identical twin drugs) or different (nonidentical twin drugs). Identical twin drugs can act on receptors (biogenic amine receptors, peptide receptors, Ca2+ channel, σ receptors in the brain, leukotriene B4 receptors), as enzyme inhibitors (HIVenzyme, protein kinase, prolyl hydrolase, acyl-CoA cholesterol acyl transferase, spermidine- spermine-N1-acetyltransferase, S-adenosylmethionine decarboxylase), and as DNA ligands. Nonidentical twin drugs exert their dual action on two different receptors, on two binding sites of a single receptor, on two enzymes, or on both a receptor and an enzyme.

Ključne riječi
twin drugs; receptors; enzymes

Hrčak ID: 29417

URI
https://hrcak.srce.hr/29417

[hrvatski]

Posjeta: 1.038 *