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Regulation of Pentose Catabolic Pathway Genes of Aspergillus niger

Marco J.L. de Groot ; Fungal Genomics, Wageningen University, Dreijenlaan 2, NL-6703 HA Wageningen, The Netherlands
Carline van den Dool ; Microbiology, Utrecht University, Padulaan 8, NL-3584 CH Utrecht, The Netherlands
Han A.B. Wösten ; Microbiology, Utrecht University, Padulaan 8, NL-3584 CH Utrecht, The Netherlands
Mark Levisson ; Fungal Genomics, Wageningen University, Dreijenlaan 2, NL-6703 HA Wageningen, The Netherlands
Patricia A. vanKuyk ; Fungal Genomics, Wageningen University, Dreijenlaan 2, NL-6703 HA Wageningen, The Netherlands
George J.G. Ruijter ; Fungal Genomics, Wageningen University, Dreijenlaan 2, NL-6703 HA Wageningen, The Netherlands
Ronald P. de Vries ; Microbiology, Utrecht University, Padulaan 8, NL-3584 CH Utrecht, The Netherlands

Sažetak

The aim of this study was to obtain a better understanding of the pentose catabolism in Aspergillus niger and the regulatory systems that affect it. To this end, we have cloned and characterised the genes encoding A. niger L-arabitol dehydrogenase (ladA) and xylitol dehydrogenase (xdhA), and compared the regulation of these genes to other genes of the pentose catabolic pathway. This demonstrated that activation of the pathway depends on two transcriptional regulators, the xylanolytic activator (XlnR) and an unidentified L-arabinose specific regulator (AraR). These two regulators affect those genes of the pentose catabolic pathway that are related to catabolic conversion of their corresponding inducers (D-xylose and L-arabinose, respectively).

Ključne riječi

Aspergillus niger; pentose catabolism; XlnR; AraR; L-arabinose; D-xylose

Hrčak ID:

27130

URI

https://hrcak.srce.hr/27130

Datum izdavanja:

4.6.2007.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.870 *