Izvorni znanstveni članak

https://doi.org/10.5599/admet.2967

Intranasal carvacrol nanoemulsion: Stroke imaging and neuroprotective study

Hitendra Mahajan orcid.org/0000-0001-6648-144X ; R C Patel Instituted of Pharmaceutical Education and Research Shirpur *
Ghanshyam Girnar ; R C Patel Instituted of Pharmaceutical Education and Research Shirpur

* Dopisni autor.

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Sažetak

Background and purpose: Cerebral ischemia causes neuronal damage due to restricted blood flow and presents significant challenges for brain-targeted drug delivery because of the blood-brain barrier. The purpose of this study is to formulate and evaluate an intranasal oil-in-water nanoemulsion of carvacrol, a neuro­protective agent, for direct nose-to-brain delivery in treating cerebral ischemia. Experimental approach: Nano­emulsions were developed using high-pressure homogenization and optimized by adjusting surfactant mixture ratios and homogenization cycles. Characterization included droplet size (

Ključne riječi

Nose to brain; radiolabelling; gamma scintigraphy; middle cerebral artery occlusion

Hrčak ID:

345197

URI

https://hrcak.srce.hr/345197

Datum izdavanja:

3.12.2025.

Posjeta: 221 *