Professional paper

SERUM URIC ACID LEVELS IN PATIENTS WITH ACUTE CORONARY SYNDROME ACCORDING TO RENAL FUNCTION

Ivan Zeljko ; Department of Internal Medicine, University Clinical Hospital Mostar, Bijeli brijeg bb, 88 000 Mostar, Bosnia & Herzegovina & Faculty of Medicine, University of Mostar, Zrinskog Frankopana 34, 88 000 Mostar, Bosnia & Herzegovina *
Kornelija Jurčić Bulić ; Department of Internal Medicine, University Clinical Hospital Mostar, Bijeli brijeg bb, 88 000 Mostar, Bosnia & Herzegovina
Ivana Ljubić Zeljko ; Department of Ophthalmology, University Clinical Hospital Mostar, Bijeli brijeg bb, 88 000 Mostar, Bosnia & Herzegovina
Ivan Mustapić ; Department of Internal Medicine, University Clinical Hospital Mostar, Bijeli brijeg bb, 88 000 Mostar, Bosnia & Herzegovina
Domagoj Tomić ; Department of Internal Medicine, University Clinical Hospital Mostar, Bijeli brijeg bb, 88 000 Mostar, Bosnia & Herzegovina
Ivan Tomić ; Department of Internal Medicine, University Clinical Hospital Mostar, Bijeli brijeg bb, 88 000 Mostar, Bosnia & Herzegovina & Faculty of Medicine, University of Mostar, Zrinskog Frankopana 34, 88 000 Mostar, Bosnia & Herzegovina

* Corresponding author.

Abstract

Introduction: Elevated serum uric acid has been associated with adverse cardiovascular outcomes and impaired renal function. Its role in patients with acute coronary syndrome (ACS) remains insufficiently clarified, particularly in relation to estimated glomerular filtration rate (eGFR). The aim of our study was to analyze serum uric acid levels in patients with ACS according to renal function assessed by eGFR.
Subjects and Methods: This retrospective study included 149 patients hospitalized with ACS at the University Clinical Hospital Mostar between October 2024 and March 2025. Patients were divided according to serum uric acid levels and renal function status (normal vs. reduced eGFR). Data were collected from medical records and analyzed using appropriate descriptive and inferential statistical methods.
Results: Reduced eGFR was observed in a significantly higher proportion of patients with ACS compared to normal renal function (p < 0.001). Patients with reduced eGFR had significantly higher serum uric acid levels than those with preserved renal function (p < 0.001). A strong negative correlation between uric acid levels and eGFR was identified (r = −0.648, p < 0.001).
Conclusion: Elevated serum uric acid levels are significantly associated with reduced renal function in patients with ACS. Uric acid may represent a useful marker for identifying patients at higher risk of renal impairment and adverse outcomes in the setting of ACS.

Keywords

acute coronary syndrome; uric acid; eGFR; renal function; cardiovascular risk

Hrčak ID:

347501

URI

https://hrcak.srce.hr/347501

Publication date:

29.5.2026.

Article data in other languages: croatian

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