ADMET and DMPK, Vol. 14 , 2026.
Izvorni znanstveni članak
https://doi.org/https://doi.org/10.5599/admet.3384
Zn-Ni metal-organic framework nanosheets@graphene oxide nanocomposite: A promising voltammetric platform for sensitive determination of doxorubicin
Tahereh Kondori
; Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
*
Niloufar Akbarzadeh-T
; Department of Chemistry, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran
Somayeh Tajik
; Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
Hadi Beitollahi
; Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
*
* Dopisni autor.
Sažetak
Background and purpose: Doxorubicin (DOX) serves as an anthracycline-based chemotherapy drug to treat multiple types of cancers and sarcomas, which include lung, breast, bladder, leukaemia, liver, head and neck cancers. Experimental approach: The electroanalysis of the trace level of DOX in this study was conducted using a Zn-Ni metal-organic framework nanosheets@graphene oxide nanocomposite (Zn-Ni MOF NSs@GO) after the modification of a screen-printed carbon electrode (Zn-Ni MOF NSs@GO/SPCE). Using chronoamperometry, cyclic voltammetry and differential pulse voltammetry, the electrochemical characteristics of the sensor as constructed for DOX measurement were examined. Key results: Consequently, the composite sensor demonstrated exceptional electrocatalytic performance in oxidizing DOX within a concentration range of 0.004 to 190.0 μM, with a detection limit of 0.001 μM. It was found that the Zn-Ni MOF NSs@GO/SPCE was effective at determining DOX in real samples, with good recovery values in the 97.1 to 102.0 % range. Conclusion: The designed sensor with cost-effective and good performance could be valuable for therapeutic drug monitoring and clinical diagnostics.
Ključne riječi
Cancer; differential pulse voltammetry; voltammetric sensor; real sample; synergistic interaction
Hrčak ID:
350225
URI
Datum izdavanja:
8.7.2026.
Posjeta: 0 *