ADMET and DMPK, Vol. 14 , 2026.
Original scientific paper
https://doi.org/10.5599/admet.2967
Intranasal carvacrol nanoemulsion: Stroke imaging and neuroprotective study
Hitendra Mahajan
orcid.org/0000-0001-6648-144X
; R C Patel Instituted of Pharmaceutical Education and Research Shirpur
*
Ghanshyam Girnar
; R C Patel Instituted of Pharmaceutical Education and Research Shirpur
* Corresponding author.
Abstract
Background and purpose: Cerebral ischemia causes neuronal damage due to restricted blood flow and presents significant challenges for brain-targeted drug delivery because of the blood-brain barrier. The purpose of this study is to formulate and evaluate an intranasal oil-in-water nanoemulsion of carvacrol, a neuroprotective agent, for direct nose-to-brain delivery in treating cerebral ischemia. Experimental approach: Nanoemulsions were developed using high-pressure homogenization and optimized by adjusting surfactant mixture ratios and homogenization cycles. Characterization included droplet size (
Keywords
Nose to brain; radiolabelling; gamma scintigraphy; middle cerebral artery occlusion
Hrčak ID:
345197
URI
Publication date:
3.12.2025.
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