Pregledni rad

https://doi.org/10.20471/acc.2025.64.04.17

A Systematic Review of Cerebral Atrophy in Ischemic Stroke

Fahad Somaa ; King Abdulaziz University, Occupational Therapy Department, Faculty of Medical Rehabilitation Sciences, Jeddah, Saudi Arabia *
Azka Khan ; Riphah International University, Faculty of Rehabilitation and Allied Health Sciences Islamabad, Pakistan
Anna Podlasek ; NIHR Nottingham BRC, University of Nottingham, Nottingham, UK; Clinical Radiology, Queens Medical Centre - Nottingham University Hospitals NHS Trust, Nottingham, UK
Faraz Ahmed Bokhari ; Department of Physiology, Shaikh Zayed Federal FPGMI, Lahore, Pakistan

* Dopisni autor.

Sažetak

Background: Stroke, a neurological condition, ranks as the second leading cause
of death and disability worldwide, resulting in sensory, motor and cognitive impairments. Post-stroke
cerebral atrophic changes in various brain regions, both ipsilesional and contralesional, carry significant
clinical implications. This systematic review and meta-analysis aims to explore structural (volume and
cortical thickness) and functional deficits induced by post-ischemic stroke cerebral atrophy.
Methods: The review encompassed studies conducted from January 2010 to October 2021, resulting
in the inclusion of 33 articles sourced from PubMed/Medline, Cochrane/EMBASE and PEDro
databases. Keywords such as ‘stroke’, ‘cortical atrophy’, ‘cerebral atrophy’, ‘motor’, ‘sensory’ and ‘cognitive
disability’ were utilized in the search process.
Results: Notably, the temporal lobe emerged as the most commonly affected site for atrophic volume
changes, followed by the thalamic areas, hippocampus, cerebellum and sensory cortex. Cortical
thinning was observed in frontotemporal, inferior parietal, primary motor cortex (M1) and superior
frontal gyrus regions of the stroke hemisphere. Regarding functional outcomes, gray matter volume
(GMV) was found to correlate with motor function, with severe GMV atrophy hindering clinical recovery,
while increased GMV was linked to better outcomes. Additionally, GMV was associated with
cognitive functions. Notably, changes in total and regional brain tissue volume were observed early poststroke
and continued at an accelerated rate compared to normal age-related atrophic changes.
Conclusion: This underscores the potential of brain atrophy as a prognostic marker for identifying
regions of structural plasticity and as a therapeutic target.

Ključne riječi

Stroke; Cortical atrophy; Cerebral atrophy; Motor, sensory and cognitive impairment

Hrčak ID:

344731

URI

https://hrcak.srce.hr/344731

Datum izdavanja:

31.12.2025.

Podaci na drugim jezicima: hrvatski

Posjeta: 426 *