ADMET and DMPK, Vol. 6 No. 2, 2018.

Table of contents

Full text

Chromatographic technique to support ADMET&DMPK in early drug discovery (page 71-73)

Klara Valko
Editorial

The role and impact of high throughput biomimetic measurements in drug discovery (page 74-84)

Shenaz Bunally, Robert J. Young
Review article

Leveraging chromatography based physicochemical properties for efficient drug design (page 85-104)

Gilles H. Goetz, Marina Shalaeva
Review article

Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate – mass action model for data analysis and simulation to improve design of experiments (page 105-139)

Alex Avdeef
Review article

Estimation of skin permeation by liquid chromatography (page 140-152)

Sara Soriano-Meseguer, Elisabet Fuguet, Adriana Port, Martí Rosés
Original scientific paper

Lipophilicity determination of acidic compounds: MEEKC as a reliable high-throughput methodology (page 153-161)

Xavier Subirats, Lídia Redón, Martí Rosés
Original scientific paper

Application of biomimetic HPLC to estimate lipophilicity, protein and phospholipid binding of potential peptide therapeutics (page 162-175)

Klara Valko, Gabriela Ivanova-Berndt, Paul Beswick, Mark Kindey, Dorothy Ko
Original scientific paper

In vitro biomimetic HPLC and in vivo characterisation of GM6, an endogenous regulator peptide drug candidate for amyotrophic lateral sclerosis (page 176-189)

Klara Valko, Mark Kindy, James Evans, Dorothy Ko
Original scientific paper

Peptide retention time prediction for immobilized artificial membrane phosphatidylcholine stationary phase: method development and preliminary observations (page 190-199)

Daniel Gussakovsky, Haley Neustaeter, Victor Spicer, Oleg V. Krokhin
Original scientific paper

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